ncRNA name | mmu-miR-451a |
ncRNA Category | miRNA |
Disease name | diabetic retinopathy (DR) |
Species | Mus musculus |
Tissues/Cell_line | retinas |
Methods | immunostaining, luciferase reporter assay, transfection, CCK-8 assay, wound healing assay, qRT-PCR, Western blot |
Expression pattern | down-regulated |
Functional description | miR-451a/ATF2 plays a vital role in the regulation of proliferation and migration in RPE cells through regulation of mitochondrial function, which may provide new perspectives for developing effective therapies for PDR. |
PubMed ID | 30576241 |
Year | 2019 |
Title | miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy. |
Drug-related ncRNA | NO |
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